Alternative therapies for treating chronic pain in older adults: an integrative review of clinical trials
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Keywords

Elderly
Chronic Pain
Alternative Therapies
Non-Pharmacological Intervention
Quality Of Life
Pain Management

How to Cite

Roston, B. C. de M. B. (2025). Alternative therapies for treating chronic pain in older adults: an integrative review of clinical trials. Journal of Medical Residency Review, 4(00), e099. https://doi.org/10.37497/JMRReview.v4i00.99

Abstract

Background: Population aging has increased the prevalence of chronic diseases and multimorbidities, including chronic pain, which affects more than half of the elderly and impacts functionality, autonomy, and quality of life. Physiological changes, increased central sensitization, and the presence of comorbidities aggravate this condition, requiring integrated and safe care approaches. In this context, non-pharmacological therapies emerge as promising alternatives for pain management in the elderly, reducing risks associated with prolonged use of analgesics.

Aim: To conduct a literature review on alternative therapies used in the treatment of chronic pain in older adults.

Method: Integrative review conducted in the PUBMED database, using the strategy: (geriatr[title] OR elderly[title]) AND chronic[title] AND pain[title]*, considering articles published in the last 10 years. Studies that exclusively addressed non-pharmacological interventions were included. Results: The initial search identified 18 articles; after excluding studies focused on pharmacological therapies, 11 comprised the final sample. The interventions evaluated included physical exercise, health education, adapted yoga, muscle stabilization, virtual reality, acupuncture, hypnosis, radiofrequency ablation, and complementary therapies. Most studies reported reduced pain intensity, functional improvement, and a positive impact on quality of life. Techniques such as radiofrequency ablation and yin-yang acupuncture had particularly robust effects, while interventions such as vagal stimulation by abdominal vibrations showed limited efficacy, although they were safe and well tolerated.

Conclusion: Alternative therapies are effective and safe strategies for managing chronic pain in older adults, offering multidimensional benefits. The literature reinforces the need for multimodal, individualized, and integrated approaches, as well as additional research to improve protocols, identify response profiles, and expand the clinical applicability of these interventions.

https://doi.org/10.37497/JMRReview.v4i00.99
PDF (Português (Brasil))

References

ARAZI, Sadegh et al. The Effect of a Non-Pharmacological Multicomponent Pain Management Program on Pain Intensity and Quality of Life in Community-Dwelling Elderly Men With Chronic Musculoskeletal Pain. Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses, v. 24, n. 3, p. 311–317, jun. 2023.

BILLOT, Maxime et al. Hypnosis Program Effectiveness in a 12-week Home Care Intervention To Manage Chronic Pain in Elderly Women: A Pilot Trial. Clinical Therapeutics, v. 42, n. 1, p. 221–229, jan. 2020.

BLOOM, David E. et al. Macroeconomic implications of population ageing and selected policy responses. Lancet (London, England), v. 385, n. 9968, p. 649–657, 14 fev. 2015.

BOEHNKE, Kevin F. et al. Feasibility study of a modified yoga program for chronic pain among elderly adults in assisted and independent living. Explore (New York, N.Y.), v. 18, n. 1, p. 104–107, 2022.

BRUYÈRE, Olivier; DEMONCEAU, Céline; KERGOAT, Marie-Jeanne. Navigating the Health Care Landscape for an Ageing Population: An International Survey of Strategies and Priorities. Journal of the American Medical Directors Association, v. 25, n. 9, p. 105155, set. 2024.

COLLABORATORS, GBD 2021 Demographics; BAKER, Jennifer Lyn. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950-2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet, v. 403, n. 10440, p. 1989–2056, 18 maio 2024.

DAGNINO, Ana P. A.; CAMPOS, Maria M. Chronic Pain in the Elderly: Mechanisms and Perspectives. Frontiers in Human Neuroscience, v. 16, p. 736688, 2022.

ESHUIS, Thom A. H. et al. Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: A pilot study. PloS One, v. 16, n. 11, p. e0259394, 2021.

FENG, Zhanlian et al. Long-term care system for older adults in China: policy landscape, challenges, and future prospects. Lancet (London, England), v. 396, n. 10259, p. 1362–1372, 24 out. 2020.

GRUBER, Jonathan et al. China’s Social Health Insurance in the Era of Rapid Population Aging. JAMA Health Forum, v. 6, n. 4, p. e251105, 25 abr. 2025.

HUA, Kaiyu et al. Integrating social, climate and environmental changes to confront accelerating global aging. BMC public health, v. 24, n. 1, p. 2838, 15 out. 2024.

LEI, Yifan et al. [Acupuncture with yin-yang regulation method for chronic low back pain in elderly patients with lumbar disc herniation: a randomized controlled Trial]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, v. 45, n. 5, p. 620–626, 12 maio 2025.

MA, Yingcun et al. Ultrasound-Guided Radiofrequency Ablation for Chronic Osteoarthritis Knee Pain in the Elderly: A Randomized Controlled Trial. Pain Physician, v. 27, n. 3, p. 121–128, mar. 2024.

RECHEL, Bernd et al. Ageing in the European Union. Lancet (London, England), v. 381, n. 9874, p. 1312–1322, 13 abr. 2013.

RITCHIE, Christine Seel et al. Impact of persistent pain on function, cognition, and well-being of older adults. Journal of the American Geriatrics Society, v. 71, n. 1, p. 26–35, jan. 2023.

RODRIGO-CLAVEROL, Maylos et al. Animal-Assisted Intervention Improves Pain Perception in Polymedicated Geriatric Patients with Chronic Joint Pain: A Clinical Trial. International Journal of Environmental Research and Public Health, v. 16, n. 16, p. 2843, 9 ago. 2019.

SCOTT, Tabitha; CANUDAS-ROMO, Vladimir. Decomposing the Drivers of Population Aging: A Research Note. Demography, v. 61, n. 4, p. 1011–1021, 1 ago. 2024.

SHIN, Ho-Jin et al. Thermotherapy Plus Neck Stabilization Exercise for Chronic Nonspecific Neck Pain in Elderly: A Single-Blinded Randomized Controlled Trial. International Journal of Environmental Research and Public Health, v. 17, n. 15, p. 5572, 1 ago. 2020.

SOROUSH, Sima et al. The effects of neck, core, and combined stabilization practices on pain, disability, and improvement of the neck range of motion in elderly with chronic non-specific neck pain. Work (Reading, Mass.), v. 71, n. 4, p. 889–900, 2022.

STOMPÓR, Małgorzata et al. Prevalence of Chronic Pain, Particularly with Neuropathic Component, and Its Effect on Overall Functioning of Elderly Patients. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, v. 25, p. 2695–2701, 12 abr. 2019.

SYED, Muslim Abbas; SYED, Mohamed Ahmed; LEE, Andrew C. K. Healthy ageing - Investing now for the future. Public Health, v. 240, p. 95–96, mar. 2025.

TINNIRELLO, Andrea; MAZZOLENI, Silvia; SANTI, Carola. Chronic Pain in the Elderly: Mechanisms and Distinctive Features. Biomolecules, v. 11, n. 8, p. 1256, 23 ago. 2021.

WHITLOCK, Elizabeth L. et al. Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders. JAMA Internal Medicine, v. 177, n. 8, p. 1146–1153, 1 ago. 2017.

WU, Nina et al. Trends in health service needs, utilization, and non-communicable chronic diseases burden of older adults in China: evidence from the 1993 to 2018 National Health Service Survey. International Journal for Equity in Health, v. 22, n. 1, p. 169, 30 ago. 2023.

YALFANI, Ali; ABEDI, Mitra; RAEISI, Zahra. Effects of an 8-Week Virtual Reality Training Program on Pain, Fall Risk, and Quality of Life in Elderly Women with Chronic Low Back Pain: Double-Blind Randomized Clinical Trial. Games for Health Journal, v. 11, n. 2, p. 85–92, abr. 2022.

YUEN, John W. M. et al. The effects of Gua sha on symptoms and inflammatory biomarkers associated with chronic low back pain: A randomized active-controlled crossover pilot study in elderly. Complementary Therapies in Medicine, v. 32, p. 25–32, jun. 2017.

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